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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)

Farmasi
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Published by Universitas Wahid Hasyim Semarang

ISSN : 16937899 EISSN : 27163814 DOI : 10.31942

Core Subject : Health,

Medicine & Pharmacology

Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.

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PENGARUH VARIASI KADAR AMILUM GARUT (Maranta arundinaceae Linn) SEBAGAI BAHAN PENGIKAT TERHADAP SIFAT FISIK DAN KIMIA TABLET PARASETAMOL Sugiyono Sugiyono; Pipit Murdiyani; Yulias Ninik Windriyati
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.9 No.2 Desember 2012
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Starch had a characteristic that could be used as a binder. Arrowroot starch containing amylose and amylopectin which could be used as a binder. Paracetamol had the flow properties and compactibility badly, it was necessary to make granules by wet granulation method (Voigt, 1984). This study aimed to determine the influence of variations in levels of arrowroot starch as a binder to the physical and chemical properties of paracetamol tablets. This research was conducted by mixing paracetamol with mucilago amylum arrowroot (FI: 5%, FII: 7.5%, FIII: 10%, FIV: 12.5%, and FV: 15%) and were given lactose, sifted, and dried. Granules sifted back, plus primogel and magnesium stearate. Mixed granules tested flow rate, rupose angle and tapping index . The granules was then into tablet and then their physical properties were observed, including weight uniformity, hardness, brittleness, and dissolving time.The active substance content was decided based on Farmakope Indonesia Edisi III. The data gathered were then analyzed theoretically by comparing then against what were stated in the literature and statistic cally tested by using one way ANAVA with a confidence degree of 95%, which was then furthered by using the Tuckey test. The result that the starch contained in the arrowroot could be used as a paracetamol tablet binder. Tablets of all formulas met the requirements of a good tablet physical properties. Hardness and tablet disintegration time increased with increasing levels of arrowroot starch as binder, while the fragility of the tablet decreased. Key words: arrowroot amylum, binder, Tablet parasetamol

PERBEDAAN PENGARUH LAMA PENYIMPANAN LARUTAN SUSU BUBUK FULL CREAM DAN LARUTAN SUSU KENTAL MANIS TERHADAP KADAR GLUKOSA Risha Fillah Fithria; Agus Suprijono; Maywan Hariono
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.9 No.2 Desember 2012
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTMilk and the products which have expired usually be thrown by people immediately.However, those are still having lactose content even do not like as much as a fresh milk. Lactose content of milk and the expired products can be extracted and then hydrolized to yield glucose and galactose. The glucose content can be determined, so it will give information about ehancing value of expired milk that the glucose content can be developed furthermore to larger scale (industrial scale). This research was aimed to know influence of storage duration toward glucose content of fresh milk, full cream milk powder solution and sweet concentrate milk solution, and comparison of glucose content for each product. Research object was glucose content of fresh milk, full cream milk powder solution and sweet concentrate milk solution which was store for 0, 1, 2, 3, 4 and 5 days with gravimetric methode and determined by Friedman test; comparison of glucose content for each product determined by Anova because its distribution are normal and its variation are homogen, or by Kruskal-Wallis because its distribution are unnormal and its variation are unhomogen using SPSS version 15.0 with level of statistic confidence 99%. The result showed that the storage duration was influenced toward glucose content of fresh milk, full cream milk powder solution and sweet concentrate milk solution significantly and there are significance difference of glucose content for each products with the manipulation on storage duration.Key words : storage duration, glucose, fresh milk, full cream milk powder solution and sweet concentrate milk solution

EVALUASI KANDUNGAN VITAMIN CDALAM MADU RANDU DAN MADU KELENGKENG DARI PETERNAK LEBAH DAN MADU PERDAGANGAN DI KOTA SEMARANG Aqnes Budiarti; Sumantri Sumantri; Diah Fahmisul Istiyaningrum
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.9 No.2 Desember 2012
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Key words: vitamin C, cottonwoods honey, longan honey, HPLC Honey is a natural product that containing several vitamins, including vitamin C, which has an important role to maintain health, among others helps healing wound, increase body resistance fight infection and as antioxidant. This research aimed to determine the levels of vitamin C in the cottonwoods honey and longan honey from beekeepers and honey trade in the city of Semarang using HPLC.Samples consisted of three samples of honey and three cottonwoods honey and longan honey from beekeepers different (Ambarawa, Ngaliyan, Gringsing) and honey trade in the city of Semarang. HPLC (waters ec 2695) operational conditions is equipped stationary phase C18 column (C18 5um sunfire; 4.6 X150 mm), and the mobile phase is a mixture of phosphate buffer pH 3.6 and acetonitrile with the ratio 70: 30, v / v, flow rate of 0.5 ml / min. Detection use UV detector (UV / vis water in 2489) at 260 nm wavelength.Research results show ed that the average levels of vitamin C in the cottonwoods honey from beekeepers and honey cottonwoods trade in the city of Semarang are 0,034% and 0,016%, while for longan honey respectively 0,027% and 0,032%. The average level of the twelve samples of honey contain vitamin C, but there are two samples that does not contain vitamin C. There was no significant difference between the levels of vitamin C and cottonwoods honey and longan honey from beekeepers and honey trade in the City of Semarang.

Daftar Isi dan Redaksi Jurnal Farmasi & Farmasi Klinik Vol.10 No.1 Juni 2013 farmasi farmasi
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.10 No.1 Juni 2013
Publisher : Universitas Wahid Hasyim Semarang

Jurnal Ilmu Farmasi & Farmasi KlinikJournal of Pharmaceutical Science & Clinical Pharmacy DAFTAR ISI ISSN : 1693-7899Volume 10 No 1 Juni 2013Perbandingan Kadar Sukrosa Dalam Madu Randu dan Madu Kelengkeng dari Peternak Lebah dan Madu Perdagangan di Kota Semarang Sumantri, Aqnes Budiarti, Indah parameita………………………………………….. 1 - 6Kajian Kualitas Air Sumur Sebagai Sumber Air Minum di Kelurahan Gubug Kecamatan Gubug Kabupaten Grobogan Aqnes Budiarti, Rupmini, Henna Rya Soenoko……………………………………… 7 - 12Aktivitas Stimulansia Ekstrak Etanol Bunga dan Daun Cengkeh (Syzygium aromaticum (L) Merr. & Perry.) Pada Mencit Jantan Galur Swiss Beserta Identifikasi Golongan Senyawa Aktifnya Yance Anas, Niken Puspitasari, Maulita Cut Nuria………………………………….. 13 - 22Uji Aktivitas Imunostimulator Fraksi Etil Asetat Ekstrak Etanol Kelopak Bunga Rosella (Hibiscus sabdariffa L.) Terhadap Proliferasi Sel Limfosit Mencit Galur Swiss Secara In Vitro Beserta Identifikasi Kandungan Senyawa Kimianya Nirmalasari, Maria Ulfah, Ediati Sasmito……………………………………………. 23 - 30Pengaruh Penggunaan Amilum Biji Durian (Durio Zibethinus L.) Sebagai Bahan Penghancur yang Ditambahkan Secara Internal-Eksternal Terhadap Sifat Fisik dan Kimia Tablet Ibuprofen Sugiyono, Hilda Shofia Afriliana, Yulias Ninik W…………………………………... 31 - 35Aktivitas Mukolitik Fraksi Metanol dari Ekstrak Etanol Daun Sirih Merah (Piper crocotum Ruiz and Pav.) Pada Mukosa Usus Sapi dan Kandungan Kimianya. Ririn Lispita Wulandari, Yulias Ninik Windriyati, Aqnes Budiarti…………………... 36 - 44

PERBANDINGAN KADAR SUKROSA DALAM MADU RANDU DAN MADU KELENGKENG DARI PETERNAK LEBAH DAN MADU PERDAGANGAN DI KOTA SEMARANG Sumantri Sumantri; Aqnes Budiarti; Indah Parameita
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.10 No.1 Juni 2013
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Key words: cottonwoods honey, longan honey, sucrose, KCKT Honey is a natural liquid that generally has a sweet taste and produced by the bees. Along with the increase in consumption of honey, honey adulteration grew a way to get the benefits. Sucrose sugar often added because its price is relative cheap. The content of sucrose become a measurement of the authenticity of honey. The spurious honey harm consumers because of different composition so that its benefits are also different.The purpose of this research is to determine the sucrose content and the quantitation of sucrose in longan honey and honey cottonwoods from beekeepers and honey trade in the City of Semarang using HPLC.Honey samples were taken randomized with three sample of cottonwoods and three longan honey from beekeepers area in Ngaliyan, Gringsing dan Ambarawa and honey trade in the City of Semarang. The determination of sucrose using HPLC system (Waters ec 2695) equipped with C18 column (C18 5um Sunfire; 4.6 x150mm) and detector UV (UV/Visible Waters 2489) at wavelength 190 nm. Mobile phase consisted of a mixture of acetonitrile and aquabides (75:25, v/v) with a flow rate of 1.0 mL/min.Research results showed that the average content of sucrose in honey samples cottonwoods and longan honey from beekeepers respectively 4,03% dan 2,98%, while the average level for the sample of cottonwoods and longan honey trade in the City of Semarang respectively 2,11% and 2,59%. The average level of sucrose from twelve samples meet requirements but the there are two samples that does not comply requirement of honey based on SNI-2004. There was no significant difference between the levels of sucrose honey cottonwoods and honey longan from beekeepers and honey trade in the City of Semarang.

KAJIAN KUALITAS AIR SUMUR SEBAGAI SUMBER AIR MINUM DI KELURAHAN GUBUG KECAMATAN GUBUG KABUPATEN GROBOGAN Aqnes Budiarti; Rupmini Rupmini; Henna Rya Soenoko
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.10 No.1 Juni 2013
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Most of Grobogan people use well water facilities to fulfill water requirement every day. This study aim to evaluate well water quality that used as water drinking resourses in Gubug Grobogan and to determine well water meet the requirement as Regulation of Health Minister No. 416/Menkes/Per/IX/1990. This study is non-experimental research with descriptive analysis. Parameter of water quality that investigated comprised physical parameter, chemical parameter and microbiological parameter. Sample have been taken by simple random sampling from three types of well in Gubug, that is well near the garbage disposal, well near the Gubug village river which all along the river there are tofu factory "Bintang Timur" and syrup factory "Kartika", and well which were far from garbage disposal and gubug village river. Samples were determined by atomic absorption spectrofotometry for cadmium parameter dan spectrofotometry for chromium parameter, and double tube multiplied method for microbiologycal parameter. Physical parameter were analysed by colorimetry, termometry, turbidimetry and TDS meter. The results showed that well water quality in Gubug Grobogan based on physical parameter have appropiated with standard but well near the Gubug village river have not appropiated with colour standard. Based on chemical parameter, the three type of well have appropiated with standard for cadmium and chromium concentration. While based on mikrobiologycal parameter Coliform total have not appropiated with standard.Key words : quality study, well water, water drinking

AKTIVITAS STIMULANSIA EKSTRAK ETANOL BUNGA DAN DAUN CENGKEH (Syzygium aromaticum (L) Merr. & Perry.) PADA MENCIT JANTAN GALUR SWISS BESERTA IDENTIFIKASI GOLONGAN SENYAWA AKTIFNYA Yance Anas; Niken Puspitasari; Maulita Cut Nuria
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.10 No.1 Juni 2013
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Keywords : Cloves’ buds and leaves (Syzygium aromaticum (L) Merr. & Perry.) ethanol extracts, stimulant, locomotoric activity, hole-board, open field, terpenoid, alkaloids One of the clove properties is as a stimulant. The purposes of this experimental study were to investigate stimulant effect of clove’s buds and leaves ethanol extracts through locomotoric activity studies on male Swiss strain mice and to identify its active compounds. The experiment was performed with pretest and posttest control group design. Thirty two mice ware divided into eight treatment groups. Locomotoric activity study was performed with hole-board and open-field method. Mice in group I (negative control) provide orally CMC-Na 1% 25 mL/kg BW. Mice in group II (caffeine group) provided orally caffeine 25 mg/kg BW. Six other treatment groups provide clove’s buds and leaves ethanol extracts (100, 200, and 400) mg/kg BW respectively. Frequency of mice head-deeping into holes in the floor and duration of movement in 5 minutes were accessed before and after treatment with extract. Data analyzed using paired-sample T test (p: 0.95). The result showed clove’s buds and leaves ethanol extracts to have stimulant properties on male Swiss strain mice through enhancing locomotoric activity in hole-board method (p<0.05). Clove’s buds and leaves ethanol extracts (100, 200 and 400) mg/Kg BW treatment on male Swiss strain mice can significantly increase mice head-deeping frequency into holes in the floor and exploratory behavior (p<0.05). There was no significant different on mice duration movement (p>0.05). Terpenoid and alkaloid active compounds in clove’s buds and leaves ethanol extracts though to play an important role in enhancing male Swiss strain mice locomotoric activities.

UJI AKTIVITAS IMUNOSTIMULATOR FRAKSI ETIL ASETAT EKSTRAK ETANOL KELOPAK BUNGA ROSELLA (Hibiscus sabdariffa L.) TERHADAP PROLIFERASI SEL LIMFOSIT MENCIT GALUR SWISS SECARA IN VITRO BESERTA IDENTIFIKASI KANDUNGAN SENYAWA KIMIANYA Ulfah, Maria; Nirmalasari, Nirmalasari; Sasmito, Ediati
e-Publikasi Ilmiah Fakultas Farmasi Unwahas Semarang Jurnal Ilmu Farmasi & Farmasi Klinik Vol.10 No.1 Juni 2013
Publisher : e-Publikasi Ilmiah Fakultas Farmasi Unwahas Semarang

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ABSTRACTImmunostimulatory agent has an important role in the treatment of infectious disease caused bypathogen. Roselle calyx (Hibiscus sabdariffa Â immune system. The aims of this research was to know immunostimulatory activity of ethyl acetate fraction ofethanolic extract of roselle calyx on lymphocyte cell proliferation swiss strain mice and to identified thechemical compounds of the fraction.Roselle calyx was ext racted by maceration method using ethanol 96% as a solvent. The ethanolicextract was partitioned gradually by n-hexan and ethyl acetate. Series of ethyl acetate fraction were made toconcentration 10, 20, 50, 100, 200, 400 Î¼g/mL and positive control PHA 10 Î¼g/mL for tested to lymphocyte cellculture. Immunostimulatory act ivity test was done according to MTTAssay Â Key words : roselle calyx, ethyl acetate fraction, MTTAssayÂ , immunostimulatorymethod. Lymphocyte proliferat ionÂ activity was analyzed statistically to the value of Optical Density (OD) result of the Enzyme LinkedImmunosorbent Assay (ELISA) reader using Kruskal Wallis Test continued by Mann Whitney Test (p<0,05).Identificat ion of the contents phenolic compounds and flavonoids performed by Thin Layer Chromatography(TLC).The result of the research showed that ethyl acetate fraction had lymphocyte cell proliferation activity atthe concentration of 50, 100, 200, and 400 Î¼g/mL. The ethyl acetate fraction of roselle calyx contained phenoliccompounds and flavonoids.L.) used by community as a health drink to enhance bodyâs

PENGARUH PENGGUNAAN AMILUM BIJI DURIAN (Durio Zibethinus L.) SEBAGAI BAHAN PENGHANCUR YANG DITAMBAHKAN SECARA INTERNAL-EKSTERNAL TERHADAP SIFAT FISIK DAN KIMIA TABLET IBUPROFEN Sugiyono Sugiyono; Hilda Shofia Afriliana; Yulias Ninik Windriati
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.10 No.1 Juni 2013
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Keyword : durian seeds amylum, disintegrant, ibuprofen tablets. Amylum is a polysaccharide inside plant that was saved as a food reserves in fruit seed. One of the amylum contents is amylose, essentially insoluble in cold water but can absorb large amount of water and expand, so it can be used as a disintegrant of tablets. The aim of this research is to find out the influence of the used of durian seeds amylum as a disintegrant that be added internally-externally toward the physical and chemical properties of ibuprofen tablets.Ibuprofen tablets were prepared by wet granulation method, with levels of amylum as a disintegrant were 10% which added the intragranular-extragranular with a ratio of FI (100%:0%), FII (75%:25%), FIII (50%:50%), FIV (25%:75%), FV (0%:100%). Dried granules obtained were then tested its physical properties include flow rate, angle of repose, and compressibility. Tablets were tested in terms of physical and chemical tablets properties include weight uniformity, hardness, friability, disintegration time and active substance content of tablets. Data obtained were analyzed with a theoretical approach that is done by comparing the statistical literature and that is one way ANAVA analysis with 95% confidence level, followed by a Tuckey test.The result obtained shows that all formulation complied with the requirement of good physical and chemical properties of tablet. The added of durian seeds amylum as a tablets disintegrant with internally-externally method causes difference the physical properties of disintegration time ibuprofen tablets in significant, while at hardness and friability there is no difference in significant.

AKTIVITAS MUKOLITIK FRAKSI METANOL DARI EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocotum Ruiz and Pav.) PADA MUKOSA USUS SAPI DAN KANDUNGAN KIMIANYA Ririn Lispita Wulandari; Yulias Ninik Windriyati; Aqnes Budiarti
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.10 No.1 Juni 2013
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Red betel leaves (Piper crocotum Key words: red betel leaves, mucolitic, cow’s mucous Ruiz and Pav.) can cure many kinds of diseases, including cough. The aim of this research is to determine mucolitic activity of methanol fraction from ethanol extract of red betel leaves on cow’s intestine mucous in vitro and to identify its active compound group. Ethanol extract of red betel leaves was made by maceration method using ethanol 70%. Methanol fraction was made from ethanol extract by partitioned gradually using petroleum eter, ethyl acetate, and methanol. The obtained methanol fraction was made serial concentration started from 0.1%, 0.3%, 0.5%, 0.7%, 0.9% in 80% cow’s mucous. The mucolitic activity was tested using Viscometer Rion, and 0.1% acethylcystein as positive control. Identification the active compound using thin layer chromatography. The viscosity cow’s mucous analyzed statistically. Normality test using Shapiro Wilk, non parametric statistic test using Kruskal Wallis, and then continued using Mann Whitney Test with degree of trust of 95%.The result shows that methanol fraction has mucolitic activity whether at concentration 0.3% is equivalent to 0.1% acethylcystein. Methanol fraction contains saponin, flavonoid, and polyphenol.

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